Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions of Biomaterials, Department of Polymeric Nanomaterials and Biomaterials, Institute of Polymer Science and Technology, ICTP-CSIC, Madrid, Spain Bamba, B.S.B.; Shi, J.; Tranchant, C.C.; Xue, S.J.; Forney, C.F.; Lim, L.-T.; Xu, W.; Xu, G. Coencapsulation of polyphenols and anthocyanins from blueberry pomace by double emulsion stabilized by whey proteins: Effect of homogenization parameters. Molecules 2018, 23, 2525. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Kawabata, K.; Yoshioka, Y.; Terao, J. Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols. Molecules 2019, 24, 370. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]

Similarly, research conducted in the Netherlands showed that oregano essential oil can also “prevent bacterial overgrowth and colonization in the large intestine during oral iron therapy.” Used to treat iron deficiency anemia, oral iron therapy is known to cause a series of gastrointestinal issues like nausea, diarrhea, constipation, heartburn and vomiting. Several of the active compounds found in Origanum vulgare can help aid digestion by relaxing the muscles of the GI tract and also helping balance the ratio of good-to-bad bacteria in the gut. The bacterial phospholipid cell membrane is the most important focus of intervention for OEO constituents such as terpenoids. 40 Carvacrol and thymol may decay the bacteria’s outer membrane and release its internal lipopolysaccharide compounds, increasing the permeation of adenosine triphosphate and, consequently, altering the all over passive cell permeation. 41 Several reports have recorded the great ability of OEO to inhibit the growth of several bacterial strains. 42 Giacometti, J.; Brusač Kovačević, D.; Putnik, P.; Gabrić, D.; Bilušić, T.; Krešić, G.; Stulić, V.; Barba, F.J.; Chemat, F.; Barbosa-Cánovas, G.; et al. Extraction of bioactive compounds and essential oils from Mediterra nean herbs by conventional and green innovative techniques: A review. Food Res. Int. 2018, 133, 245–262. [ Google Scholar] [ CrossRef] [ PubMed] Kim, S.; Lee, H.; Kang, S.N. Antioxidant activities of hot water extracts from various spices. Int. J. Mol. Sci. 2012, 12, 4120–4131. [ Google Scholar] [ CrossRef]In contrast, what does oil of oregano do for you that makes it so beneficial? Essentially, taking oregano oil is a “broad-spectrum approach” to protecting your health. Tavassoli-Kafrani, E.; Goli, S.A.H.; Fathi, M. Encapsulation of orange essential oil using cross-linked electrospun gelatin nanofibers. Food Bioprocess Technol. 2018, 1, 427–434. [ Google Scholar] [ CrossRef]

Bhale, S.D.; Xu, Z.; Prinyawiwatkul, W.; King, J.M.; Godber, J.S. Oregano and rosemary extracts inhibit oxidation of long-chain n-3 fatty acids in menhaden oil. Food Chem. Toxicol. 2007, 72, C504–C508. [ Google Scholar] [ CrossRef] AOAC International. Official Methods of Analysis (Method 930.15); Association of Official Analytical Chemists: Arlington, VA, USA, 1995. [ Google Scholar] Saad, R.; Asmni, F.; Saad, M.; Hussain, M.; Khan, J.; Kaleemullah, M. A new approach for predicting antioxidant propriety of herbal extracts. Int. J. Pharmacogn. Phytochem. Res. 2015, 7, 166–174. [ Google Scholar] From the information shown, it can be deduced that OEO can greatly inhibit ulcer formation in the buccal mucosa when it is in an NE. Based on a literature review, 16 , 50 we found that OEO can markedly decrease the levels of various inflammatory mediators, such as the interferon-inducible T-cell alpha chemoattractant (I-TAC), monokine induced by gamma interferon (MIG), vascular cell adhesion molecule 1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), interferon gamma-induced protein 10 (IP-10), and intracellular cell adhesion molecule 1 (ICAM-1). In addition, some investigated tissue remodeling mediators, namely, the epidermal growth factor receptor (EGRF), collagen I, and collagen III, were also markedly diminished by OEO treatment. 51 Its active ingredients help fight multiple types of harmful pathogens, including bacteria, yeast and fungi. As a study in the Journal of Medicinal Food journal stated in 2013, oregano oils “represent an inexpensive source of natural antibacterial substances that exhibited potential for use in pathogenic systems.” 2. Fights Infections and Bacterial Overgrowth

Acknowledgments

Dolca, C.; Ferrandiz, M.; Capablanca, L.; Franco, E.; Mira, E.; Lopez, F.; Garcia, D. Microencapsulation of Rosemary Essential Oil by Co-Extrusion/Gelling Using Alginate as a Wall Material. JEAS 2015, 5, 121–130. [ Google Scholar] [ CrossRef][ Green Version] Your oil of oregano dosage will depend on the condition you’re treating. In capsule form, oral supplementation of emulsified oregano is typically around 600 milligrams daily. (Either taken in one or two doses.) Fight Pneumonia and Bronchitis: For external infections, apply 2 to 3 diluted drops to the affected area. To prevent internal bacterial overgrowth, ingest 2 to 4 drops twice daily for up to 10 days. Shanmugam, A.; Ashokkumar, M. Ultrasonic preparation of stable flax seed oil emulsions in dairy systems—Physicochemical characterization. Food Hydrocoll. 2014, 39, 151–162. [ Google Scholar] [ CrossRef]