Microneedling is renowned for combating acne, with microneedle patches offering a quick and effective solution.

We've created an advanced microneedle patch that uses patented technology infused with age-defying retinol, peptides, and potent antioxidants to smooth the appearance of fine lines and wrinkles. Sodium Hyaluronate, Cellulose Gum, Glycerin, Trehalose, Propanediol, 1,2-Hexanediol, Maltodextrin, Retinol, Chlorella Ferment, Madecassoside, Tremella Fuciformis Polysaccharide, Panax Ginseng Root Extract, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Polysorbate 80, Caprylyl Glycol, Hibiscus Rosa-Sinensis Flower Extract, Butylene Glycol, Ethylhexylglycerin. In addition, HA MNP has the ability to encapsulate proteins, enzymes and antibodies in a polymer matrix.A study took place in South Korea in 2017 , where 34 women who has mild to moderate crow’s feet tested hyaluronic acid microneedle patches. suggest a mechanism: inhibition of cell surface receptor-ligand interactions by wrapping a mucoadhesive protective layer around the cell surface. More broadly, because HA is not only an endogenous substance in the skin’s surface, but also in dermis with the ability to retain cellular moisture and improve lesion healing, it can also significantly accelerate keratin-forming cell proliferation/migration and angiogenesis by inducing the production of vascular endothelial growth factor (VEGF) and adhesion molecules. Picking the right device depends on individual preferences, target areas, and specific skin concerns.

They are most commonly used to deliver hydrophilic drugs like caffeine and high-dose drugs like ibuprofen. a) Bright-field micrographs of neonatal pig skin after in vitro insertion of methylene blue-loaded MNP. Both HMW-HA and LMW-HA are effective regulators of angiogenesis, but they have opposite effects on endothelial cells (ECs) proliferation and motility (Litwiniuk et al. The Deepcare+™ serum formula worked wonders in reducing fine lines and giving my skin a nourished, plump look. Infused with our key ingredients such as Retinol, Vitamin C, Hyaluronic Acid, and the 4-Peptide Blend.

demonstrated the reaction of HA primary amines with 8-arm PEG-NHS containing succinimide-functional groups and experimentally found that the type of cross-linker had a significant effect on the swelling rate of hydrogel MNP. The fourth generation is the recent development of hydrogel MNs (hydrogel MNs prepared from substrates that swell and do not dissolve in water) (Donnelly et al. They work by comfortably hugging your décolleté and prevent the skin from being able to crease or wrinkle.