For me a game changer would be something that you take for once and it stops your hairloss for life. Or you take it and it regrows your hair improving your Norwood levels. Better than minoxidil. Kintor Pharma Announced the Primary Endpoint of Phase II Clinical Study for KX-826’s Treatment of Female Androgenetic Alopecia in China Was Met. Accessed online: https://www.prnewswire.com/news-releases/kintor-pharma-announced-the-primary-endpoint-of-phase-ii-clinical-study-for-kx-826s-treatment-of-female-androgenetic-alopecia-in-china-was-met-301691321.html

Pyrilutamide | Drug Developments | Pipeline Prospector Pyrilutamide | Drug Developments | Pipeline Prospector

Most recently, the results from the phase-2 trial conducted in the USA were released in May 2023. It was a randomized, double-blind, placebo-controlled, and parallel-group study designed to evaluate the efficacy and safety of pyrilutamide for the treatment of male pattern alopecia. A total of 123 patients were enrolled in the study. From this, 93 patients were randomly assigned to different dosage groups – 0.25% once daily, 0.5% once daily, and 0.5% twice daily. The remaining 30 patients were randomly assigned to placebo groups. Use PTSR and LOA information and event driven changes for your investment decisions to generate alpha All i know is that we're long overdue true new treatments for Androgenic Alopecia and they can't come soon enough.Kintor Pharmaceutical Limited has announced results of a phase II clinical trial of pyrilutamide (KX-826), a potential first-in-class topical drug, for the treatment of adult female androgeneticalopecia (AGA). Jianzhong Zhang, chairman of the Department of Dermatology, Peking University People’s Hospital, is the leading principal investigator. The primary endpoint for the trial is the change from baseline versus placebo in TAHC at the end of week 24. Use PTSR and LOA information and event-driven changes for your investment decisions to generate alpha PR Newswire. (2023, 28 March) Kintor Pharma Announces Completion of Subject Enrollment in Phase III Clinical Trial of KX-826 for Treatment of Male Androgenetic Alopecia in China. Bloomberg.com. Kinter, K. J., & Anekar, A. A. (2022). Biochemistry, dihydrotestosterone. In StatPearls [Internet] . StatPearls Publishing.

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In this study, 120 subjects with male androgenetic alopecia were included and randomized into four dose groups: 2.5 mg (0.25%) pyrilutamide twice a day, 5.0 mg (0.5%) once a day, 5.0 mg (0.5%) twice a day and the placebo (2,5,6). The main result of this study was the change in non-vellus target area hair count (TAHC) from the baseline and after six months of treatment. As of March 2023, 740 male patients have been enrolled in this study. This study is designed to evaluate the efficacy and safety profile of pyrilutamide for male pattern hair loss. The trial duration is 24 weeks with a 4-week follow-up. The primary endpoint is to see the change in non-vellus TAHC from baseline at the end of week 24. The results are expected by December 2023. How to use pyrilutamide? GlobalData’s ML algorithm utilizes historical data to determine the probability of successful progression and market authorization for pipeline drugs from their current development stage. The historical data set is prepared to train the ML classifier. Once the algorithm is trained and recognizes a specific pattern, it is applied to the test data. The key learning are further tuned for hyperparameters to derive the optimum model.

The drug innovator is Kintor Pharmaceutical Limited, known for developing and commercializing innovative treatments for androgen receptor-related diseases like androgenetic alopecia, acne vulgaris, and certain cancers. KX-826 is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of AGA and acne vulgaris. For the AGA indication, in September 2021, Kintor Pharma announced the primary endpoint of the phase II clinical trial of KX-826 on male adults was met, with results demonstrating a positive efficacy and safety profile.

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Store in a cool, dark place. Pyrilutamide solution maintains potency for at least two years upon mixing. Expiry date is displayed on label and only bottles with one year or more before this are shipped.GlobalData’s Drug-Specific Likelihood of Approval (LoA) models utilizes many attributes from Drugs, Clinical Trials, Review Designations and Company. The proprietary, machine learning algorithm is developed based on the impact of a specific attribute on PTSR and LoA. It's a promising treatment and time will tell what side affects are officially listed and then become known, but just like people were happy to take the COVID-19 vaccines in billions of doses without long term safety studies etc. and the side effects are still being discovered, i'm sure a scalp localised treatment for hair loss shouldn't fare too badly helping most people. There are ongoing clinical trials to prove its efficacy and safety, which may eventually lead to better accessibility and FDA approval. Pyrilutamide binds to the androgen receptor with a very high affinity with an IC 50 of 0.28 nM. [3] Reference drug bicalutamide had an IC 50 of 3.1 nM. [3] Pharmacokinetics [ edit ] I like reports that inform new segments such as the analysis on generation Z, millennials, the impact of COVID 19 to our banking customers and their new channel habits. Secondly the specialist insight on affluent sector significantly increases our understanding about this group of customers. The combination of those give us depth and breadth of the evolving market.

What Is Pyrilutamide (KX-826)? - HairScience

Personally i'm willing to give it a go when it's fully approved if its cheap enough but only alongside my current regimen. The ML model is further supplemented with an additional algorithm proprietary to GlobalData to predict PTSR and LoA. Each of the data attributes are assigned a weighted average score based on its direct impact on a drug’s clinical transition. The weighted average score represents a scale between a minimum to a maximum value based on the Raw Scores. The final score of an attribute is achieved by multiplying the Raw Score with the Weighted Score for each data attribute. All scores are added to determine the PTSR value. I did some reading. So this is topical? How much is the systemic absorption? I would not take an anti androgen orally as a male. It would have a castrating effect. If topical, biggest worry and need to know would be plasma concentration. it would work similar to topical spironolactone Those on pyrilutamide 0.5% applied twice a day exhibited statistically significant improvement in total area hair count after six months of treatment. There was an increase of 22.73 hairs per cm 2, as opposed to the placebo group which had an increase of only 15.34 hairs per cm 2. Because of these results, 0.5% pyrilutamide solution was used in the phase 3 clinical trial. Additionally, Kintor’s hair loss drug is also being explored as a treatment for acne vulgaris. The use of pyrilutamide as a treatment for acne vulgaris is still in the preclinical stage in the United States, but it’s already started phase II clinical trials in China. How Does Pyrilutamide Work for Hair Loss?The latest clinical trial data is something Matt Dominance went over in his latest YouTube video on it and in the first trials it seems they used high dosages up to 48mg and these were detectable in the bloodstream but once they readjusted dosages for Phase 2 they used 5mg as the highest dosage twice daily and at 6 months, they were claiming better gross and similar net results or better than Finasteride and Minoxodil used for even 1 year. So that to me shows a massive potential for people afraid of sides from Finasteride who never did anything at all and lost hair or those who had sides and couldn't save their hair as a result either. Pyrilutamide (KX-826) is a topical androgen receptor (AR) antagonist, being developed as a potential topical treatment for androgenetic alopecia. I could be incorrect but my understanding was that the topical nature of the product is supposed to keep it localised to the scalp AR that the DHT would usually bind to causing the hair loss. All depends on serum concentration of the drug to cause or not cause side effects. I don't completely trust this company as there have been multiple issues with their COVID drug.