An alternative to methods using UV or heat is the droplet-born air blowing method (DAB). It is suitable for drug molecules that can be inactivated. In this method, polymer droplets are placed between two sheets. As the sheets are pulled apart, the droplets elongate and the resulting needle-shaped matrices are dried by the flowing air [154,155]. A few studies have found that dissolving microneedle patches worked better than essences with the same ingredients: Chinnery,H.R.; McMenamin,P.G.; Dando,S.J. PfluegersArch. 2017, 469, 501–515. doi:10.1007/s00424-017-1947-5 Sullivan,S.P.; Murthy,N.; Prausnitz,M.R. Adv.Mater.(Weinheim,Ger.) 2008, 20, 933–938. doi:10.1002/adma.200701205

Than,A.; Liu,C.; Chang,H.; Duong,P.K.; Cheung,C.M.G.; Xu,C.; Wang,X.; Chen,P. Nat.Commun. 2018, 9, 4433. doi:10.1038/s41467-018-06981-wAmodwala,S.; Kumar,P.; Thakkar,H.P. Eur.J.Pharm.Sci. 2017, 104, 114–123. doi:10.1016/j.ejps.2017.04.001 El-Emam,G.A.; Girgis,G.N.S.; El-Sokkary,M.M.A.; El-AzeemSoliman,O.A.; AbdElGawad,A.E.G.H. Int.J.Nanomed. 2020, 15, 7825–7840. doi:10.2147/ijn.s268208

Palmitoyl pentapeptide-4 (Matrixyl orPal-KTTKS): increases production of collagen, elastin and glucosaminoglycans, can decrease photoaging and wrinklesThe paper noted that skin microneedling was a relatively minimally invasive procedure. The microneedle itself can reach down into the mid-dermis, and bleeding after application of is a common result that initiates the wound healing process. Designed to rejuvenate eyes experiencing pronounced signs of ageing and stress, the skyn ICELAND Dissolving Microneedle Eye Patches target deeper wrinkles and crow’s feet for a revitalised appearance. Working to transform this delicate area to create a more youthful illusion, the patches leave you with a complexion that seems smoother and more radiant.

Wielders,L.H.P.; Schouten,J.S.A.G.; Winkens,B.; vandenBiggelaar,F.J.H.M.; Veldhuizen,C.A.; Findl,O.; Murta,J.C.N.; Goslings,W.R.O.; Tassignon,M.-J.; Joosse,M.V.; Henry,Y.P.; Rulo,A.H.F.; Güell,J.L.; Amon,M.; Kohnen,T.; Nuijts,R.M.M.A. J.CataractRefractiveSurg. 2018, 44, 429–439. doi:10.1016/j.jcrs.2018.01.029In traditional microneedling, needle size is a major factor factor in the treatment’s effectiveness. Most people require needles that are 1.0mm or longer to reach the dermis. Tucak,A.; Sirbubalo,M.; Hindija,L.; Rahić,O.; Hadžiabdić,J.; Muhamedagić,K.; Čekić,A.; Vranić,E. Micromachines 2020, 11, 961. doi:10.3390/mi11110961 Tighsazzadeh,M.; Mitchell,J.C.; Boateng,J.S. Int.J.Pharm. 2019, 566, 111–125. doi:10.1016/j.ijpharm.2019.05.059 Prausnitz,M.R.; Jiang,J.; Patel,S.R.; Gill,H.S.; Ghate,D.; McCarey,B.E.; Geroski,D.H.; Edelhauser,H.F. Invest.Ophthalmol.VisualSci. 2007, 48, 3191. Hyaluronic acid: a humectant, water-holding ingredient that’s already present in your skin. It decreases as you age, which is partly why your skin looks less plump as you get older.

To the best of our knowledge, this is the first report on the safety and efficacy of non-absorbable Microneedle​ patches on wrinkles for 12-week usage as a home device… Further studies including a split-face study with a greater number of subjects are required.”​ Polat,H.K.; BozdağPehlivan,S.; Özkul,C.; Çalamak,S.; Öztürk,N.; Aytekin,E.; Fırat,A.; Ulubayram,K.; Kocabeyoğlu,S.; İrkeç,M.; Çalış,S. Int.J.Pharm. 2020, 585, 119552. doi:10.1016/j.ijpharm.2020.119552 Methods of drug-loading depend on the type and construction of the manufactured microneedles, as well as the applied material. The properties of the drug must be carefully taken into consideration, as some active ingredients may decompose at higher temperatures or upon irradiation. In the case of solid microneedles prepared with the use of porous ceramic materials, the pores in the carrier material can be filled with the active ingredient in liquid or solid form. In the first case, the drug diffuses from the solution in the microneedle pores upon application. In the other case, the drug solution is loaded to the microneedles and in the next step the formulation is dried and the drug precipitates inside the pores. Upon application, the drug dissolves in a physiological fluid and, in this form, can permeate to the deeper tissues [161]. In the techniques involving polymers applied to obtain solid microneedles, the drug may be dissolved [162,163] or suspended [164] in the polymer or monomer solution. In the manufacturing of more complex systems, with the active ingredient incorporated in a specific compartment of a microneedle, more complex procedures involving both drug-loaded and drug-free solutions may be employed [165]. Hollow microneedles containing an empty canal inside are usually filled with active ingredient solution, either passively or with the use of pressure-driven methods [161]. In the systems using passive diffusion, the drug solution can be loaded to the canals inside the microneedles [141] or to an external compartment [166]. In pressure-driven systems, a reservoir with different pumping mechanisms is attached to the microneedle systems. Usually, manually operated syringes are reported [167,168], as well as micropumps [169] or actuator-equipped devices designed for self-injection [170]. Prausnitz, M. R.; Jiang, N.; Edelhauser, H. F. Method for Drug Delivery to Ocular Tissue Using Microneedle. WO2007131050A3, Feb 14, 2008.Addo,E.; Bamiro,O.A.; Siwale,R. Anatomy of the Eye and Common Diseases Affecting the Eye. In Ocular Drug Delivery: Advances, Challenges and Applications; Addo,R.T., Ed.; Springer International Publishing: Cham, 2016; pp11–25. doi:10.1007/978-3-319-47691-9_2