In test tubes, saffron could also inhibit viral replication and entry into cells, potentially improving the immune system’s ability to fight off viral infections [ 9]. 9) Physical Performance Although extensive research has been conducted on saffron, a few caveats exist that limit the reliability of these studies: Research from 2015 notes that compounds in saffron, such as crocin, appear to reduce inflammation and oxidative damage in the brain, which may lead to beneficial effects. Saffron may exert this benefit by relaxing the smooth muscles of the lungs, as seen in mice. However, the exact target of saffron in the lungs is unknown and clinical trials are needed to evaluate its efficacy in humans [ 52]. 18) Digestive Issues A study in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilized to prevent bias in research results. Double-blind studies are particularly useful for preventing bias due to demand characteristics or the placebo effect.

Please could you suggest any of your products to help with my anxiety, sleeping issues and hot flashes brought on by the menopause? Study: A DB, RCT and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression by Mazidi M et al, 2016 Taking to control cravings. Found it does suppress appetite and boosts mood. Not a miracle drug though.” The active chemicals in saffron belong to a group of molecules called carotenoids. These molecules may improve energy supply and power (ergogenic effects) [ 33]. In another study on rats, the daily use of saffron inhibited the production of ulcers caused by excessive histamine or stress [ 53].In a study of 28 healthy men, saffron supplementation for 10 days increased muscle strength and improved reaction time. This is likely due to improved mitochondrial function (antioxidant activity) and procognitive effects [ 33]. The below doses may not apply to you personally. If your doctor suggests using 7-keto DHEA, work with them to find the optimal dosage according to your health condition and other factors. Curcuminoids are potent antioxidants. Alcohol consumption can cause oxidative stress that damages your cells, so an effective antioxidant is vital before, during and after a heavy night. Ettehadi, H., et al. (2013). Aqueous extract of saffron ( Crocus sativus) increases brain dopamine and glutamate concentrations in rats.

Saffron is considered a safe supplement to add to your daily regimen. Although side effects are rarely seen with saffron supplementation, some minor discomfort may occur, including [ 64]: Scientists also observed the potential of saffron to improve sexual activity in rats. This effect was mediated by the active chemical crocin [ 31].

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In 45 healthy people, saffron extract taken for 3 months significantly increased white blood cell and antibodies count (IgG and monocytes) compared to placebo [ 32]. When combined with lifestyle efforts focusing on diet, exercise, sleep and stress, the combination of bergamot fruit and artichoke leaf extracts can provide significant health benefits. Dr Paul Clayton, Fellow at The Institute of Food, Brain and Behaviour, believes saffron should be considered in place of current therapies, which he believes are outdated and on off-target. He states, “'The old model of treating anxiety and depression is obsolete. Drugs that target monoamine neurotransmitters do not work well; they take weeks to have any therapeutic effect, are rife with side effects - including, at their most extreme, psychosis and suicide, with young people being particularly at risk of the latter - and can cause very considerable withdrawal problems. The new understanding of depression and anxiety has moved on from obsessing with neurotransmitters, and focusses instead on a set of overlapping mechanisms which include chronic inflammation in parts of the central nervous system including the hypothalamus, neuronal plasticity (the ability of nerve cells to adapt, and form new connections), the stress response, and a number of deep markers such as BDNF, VGF and CREB. The actives in saffron, a sub-group of polyphenols, partition into the brain and have been shown to rapidly improve BDNF, VGF and CREB; and are well-known potent anti-inflammatory agents as well.